Determinants of Human Plasma Glutathione Peroxidase (GPx-3) Expression
نویسندگان
چکیده
منابع مشابه
Determinants of human plasma glutathione peroxidase (GPx-3) expression.
Plasma glutathione peroxidase (GPx-3) is a selenocysteine-containing protein with antioxidant properties. GPx-3 deficiency has been associated with cardiovascular disease and stroke. The regulation of GPx-3 expression remains largely uncharacterized, however, and we studied its transcriptional and translational determinants in a cultured cell system. In transient transfections of a renal cell l...
متن کاملRole of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis.
BACKGROUND AND PURPOSE Plasma glutathione peroxidase (GPx-3) is a major antioxidant enzyme in plasma and the extracellular space that scavenges reactive oxygen species produced during normal metabolism or after oxidative insult. A deficiency of this enzyme increases extracellular oxidant stress, promotes platelet activation, and may promote oxidative posttranslational modification of fibrinogen...
متن کاملNo association of the plasma glutathione peroxidase (GPx-3) gene with cerebral venous thrombosis in the German population.
No Association of the Plasma Glutathione Peroxidase (GPx-3) Gene With Cerebral Venous Thrombosis in the German Population To the Editor: In a recent publication in Stroke, cerebral venous thrombosis (CVT) was found to be associated with a variant of the plasma glutathione peroxidase (GPx-3) gene (promoter haplotype H2). The observed association was strong (OR 10) and highly significant (P 0.000...
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Background: In fertile women, glycodelin and glutathione peroxidase 3 (GPx3) genes expression rises during the luteal phase, with a peak occurring during the implantation window. The expression of these genes decreases in women with myomas. To determine whether myomectomy would reverse glycodelin and GPx3 expression, we evaluated the transcript levels of these genes in the endometrium of patien...
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Background: Oxidative stress plays a key role in the onset and development of diabetes Complications, Including diabetic cardiomyopathy. The purpose of this study was to investigate the role of dichloroacetate (DCA) on SOD and GPX expression following six weeks’ endurance training in cardiac muscle of diabetic male rats. Methods: In this experimental study, 64 male Wistar rats were selected an...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m401907200